The Rebels played their home games at Vaught-Hemingway Stadium in Oxford, Mississippi and competed in the Western Division of the Southeastern Conference (SEC).

On December 1, 2017, the University of Mississippi was dealt multiple sanctions by the NCAA, including a 2-year post-season ban.

On February 5, 2018, the university submitted a written appeal to the NCAA regarding the penalties, stating: “This Committee should vacate and reverse the penalties and factual findings, because the COI (Committee of Infractions) abused its discretion, departed from precedent, committed procedural errors, and reached factual conclusions inconsistent with the evidence.”[3] Listed in the order that they were released The SEC media poll was released on July 20, 2018, with the Rebels predicted to finish in sixth place.

The Rebels will host SEC foes Alabama, Auburn, South Carolina, and Mississippi State, and will travel to LSU, Arkansas (game played in Little Rock), Texas A&M, and Vanderbilt.

[14] The Rebels will be hosting three of their four non-conference opponents, hosting Southern Illinois (FCS), Kent State from the Mid-American Conference, Louisiana–Monroe from the Sun Belt Conference, and will then travel to Houston for their neutral site season opener against Texas Tech from the Big 12 Conference, which is the 2018 edition of the AdvoCare Texas Kickoff.