Incumbent Republican U.S. Representative Kristi Noem did not run for re-election and instead ran for governor.
Incumbent Republican governor Dennis Daugaard was term-limited and could not seek a third consecutive term.
Incumbent Republican Secretary of State Shantel Krebs did not run for re-election and instead unsuccessfully ran for Congress.
Incumbent Republican State Treasurer Rich Sattgast was term-limited and could not run for a third term.
Josh Haeder, Northeast Director for Senator Mike Rounds, ran for the Republican nomination and won.