The 2018 Texas Southern Tigers football team represented Texas Southern University a member of the West Division of the Southwestern Athletic Conference (SWAC) during the 2018 NCAA Division I FCS football season.

Led by Michael Haywood in his third and final season as head coach, the Tigers compiled an overall record of 2–9 with a mark of 1–6 in conference play, tying for fourth place in the SWAC's West Division.

Texas Southern played home games at BBVA Compass Stadium in Houston.

During the SWAC football media day held in Birmingham, Alabama on July 13, 2018, the Tigers were predicted to finish fourth in the West Division.

[1] The Tigers had one player selected to Preseason All-SWAC Teams.