The 2018 Mississippi Valley State Delta Devils football team represented Mississippi Valley State University as a member of the East Division of the Southwestern Athletic Conference (SWAC) during the 2018 NCAA Division I FCS football season.
Led by first-year head coach Vincent Dancy, the Delta Devils compiled an overall record of 1–10 and a mark of 1–6 in conference play, placing last out of five teams in the SWAC's East Division.
Mississippi Valley State played home games at Rice–Totten Stadium in Itta Bena, Mississippi.
During the SWAC football media day held in Birmingham, Alabama on July 13, 2018, the Delta Devils were predicted to finish last in the East Division.
[1] The Delta Devils had two players selected to Preseason All-SWAC Teams.