The six winning teams advance to the quarterfinals, where they are joined by the winners of Groups A and B for another round of two-legged home-and-away matches.
The four quarterfinal winners qualify for the final four tournament at the Lanxess Arena in Cologne, Germany.
On 13 March 2020, the EHF announced that the round of 16 matches would not be held as scheduled due to the ongoing coronavirus pandemic in Europe.
[3] A new competition schedule proposed by the EHF on 25 March foresees the first and second legs being played in the first week of June, with a cancellation deadline on 15 May.
[4] The final four was scheduled to be held at the Lanxess Arena in Cologne, Germany on 30 and 31 May but was rescheduled to 22 and 23 August 2020,[5][2][6] and later to 28 and 29 December 2020.