The 2019–20 U.S. Sassuolo Calcio season was the club's seventh consecutive season in the top-flight of Italian football.

The club competed in Serie A and the Coppa Italia.

Roberto De Zerbi coached the club for the second full season after replacing previous coach Giuseppe Iachini in June 2018.

Source: Competitive matches Last updated: 2 August 2020Source: Competitions

Last updated: 21 July 2020