This season is the first to follow an August–to-May schedule, as per the decision of the CAF Executive Committee on 20 July 2017.

A further 16 teams eliminated from the 2019–20 CAF Champions League enter the play-off round.

[12] On 24 November 2019, CAF made a change to all fixtures dates starting from the group stage matchday 4 to the final, due to rescheduling of the 2020 African Nations Championship from January/February to April.

[13] Following the quarter-finals, due to the COVID-19 pandemic in Africa, the semi-finals, originally scheduled for 3 May (first legs) and 10 May (second legs), were postponed indefinitely on 11 April 2020,[14] and the final, originally scheduled for 24 May, was also postponed on 18 April 2020.

[15] On 30 June 2020, the CAF Executive Committee proposed that the competition would resume with a Final Four format played as single matches in Morocco.

The draw for the play-off round was held on 9 October 2019, 19:00 CAT (UTC+2), at the Hilton Pyramids Golf in Cairo, Egypt.

The draw for the group stage was held on 12 November 2019, 12:00 CAT (UTC+2), at the CAF headquarters in Cairo, Egypt.

If away goals were also equal, then extra time was not played and the winners were decided by a penalty shoot-out.

[18] Due to the COVID-19 pandemic, the final, originally scheduled for 24 May 2020, 19:00 GMT, at the Prince Moulay Abdellah Stadium, Rabat, Morocco, was postponed until further notice.