[1] The regular season began June 12, 2019 with the opening ceremonies at the SM Mall of Asia Arena in Pasay, and ended on February 12, 2020.

[2] Nearly one year later, the playoffs resumed on March 10, 2021 with a bubble in the Subic Bay Gymnasium in Subic, Zambales before finally ending on March 21, 2021 when the Davao Occidental Tigers defeated the defending champion San Juan Knights in four games in the 2021 MPBL finals.

Western Visayas is the only region with two expansion teams in the Bacolod Master Sardines and Iloilo United Royals.

For the first time in MPBL history, the league held regular season games in international venues under its existing Invasion series.

The suspension lasted for a year, until the league were cleared by the Inter-Agency Task Force for the Management of Emerging Infectious Diseases (IATF-EID) to host a bubble at the Subic Bay Gymnasium in Olongapo, Zambales, where all remaining games were played.

Due to the COVID-19 pandemic, San Juan ended up hosting games 1 and 2, the latter being held behind closed doors.

However, game 3 was defaulted because multiple Basilan Steel members were tested positive for COVID-19 inside the bubble.

Returning events include the executives' Game, Three-Point Shootout and the Slam Dunk Contest.

[2] Commissioner Kenneth Duremdes stated in June that the suspended playoffs would continue once restrictions on contact sports have been lifted by the government.

[11] This season marked the third and final year of both ABS-CBN's and Fox Sports Asia's broadcast rights with the league.

For ABS-CBN, games were broadcast on S+A, Liga, and The Filipino Channel, while iWantTFC served as the network's international streaming platform.

On the other hand, Fox Sports Asia continued to broadcast Monday games as the league's cable partner.