They played their home games at Bryant–Denny Stadium in Tuscaloosa, Alabama, and were led by 13th-year head coach Nick Saban.

The defending national runners-up, Alabama began the season ranked second in the AP Poll, and were the favorites to repeat as SEC Champions.

The next week, Alabama lost starting quarterback Tua Tagovailoa to a season-ending hip injury in the game against Mississippi State.

With a regular season record of 10–2, Alabama was not selected for the College Football Playoff for the first time ever, having made the CFP every year since the inception of the format in 2014.

Tagovailoa, at the time of his injury, was considered a candidate for the Heisman Trophy and was on pace to break his own NCAA FBS passer rating record.

Running back Najee Harris led the team with 1,224 rushing yards and 20 total touchdowns, tied for the SEC lead.

On defense, the team was led by first-team all-conference players linebacker Anfernee Jennings and safety Xavier McKinney.

[5] Headlining the class were consensus top-10 recruits Antonio Alfano (defensive end), Trey Sanders (running back), and Evan Neal (offensive tackle).

Freshman WR John Metchie III was named A-Day MVP after hauling in five catches for a game-high 133 receiving yards.

Alabama was not scheduled to play SEC East opponents Florida, Georgia, Kentucky, Missouri and Vanderbilt in the 2019 regular season.