The 2019 Hampton Pirates football team represented Hampton University in the 2019 NCAA Division I FCS football season.

They were led by second-year head coach Robert Prunty and played their home games at Armstrong Stadium.

In the Big South preseason poll released on July 21, 2019, the Pirates were predicted to finish in sixth place.

[1] The Pirates had one player selected to the preseason all-Big South team.

On August 2, 2019, it was announced that former Florida State quarterback Deondre Francois had completed a graduate transfer to Hampton and would be immediately eligible for the upcoming season.