Los Angeles struggled early on in the season, losing four of their first five matches, and did not qualify for the Stage 1 Playoffs.
Los Angeles' season came to an end the following match, when they were swept 0–4 by the San Francisco Shock.
On August 20, Gladiators transferred main tank Baek "Fissure" Chan-hyung to Seoul Dynasty after a public dispute with the team.
[1] The team elected not to re-sign three of their players – Ted "silkthread" Wang, Luis "iRemiix" Galarza Figueroa, and Choi "Asher" Jun-sung.
On October 25, Gladiators signed DPS Jang "Decay" Gui-un and main tank Gye "rOar" Chang-hoon from Korean Overwatch Contenders team Kongdoo Panthera.
[11] Los Angeles was able to string off five more consecutive wins, putting the team at a perfect 6–0 record heading into their final regular season match of the stage against Boston Uprising.
[16] Looking to bounce back from the loss, the team next faced the Philadelphia Fusion on June 14.
The final two maps both went to overtime rounds, but the Gladiators were able to find wins on both to complete a 4–0 sweep over the Defiant.
[22] Prior to the start of Stage 4, which would include the implementation of an enforced 2-2-2 role lock by the League, the Gladiators transferred tank Kim "Bischu" Hyung-seok to the Guangzhou Charge for an undisclosed amount of cash.
Unable to overcome stellar performances by Houston's Dante "Danteh" Cruz and Alexandre "SPREE" Vanhomwegen, the Gladiators fell by a score of 1–3.
The team opened the double-elimination tournament with a match against the fourth-seeded Hangzhou Spark on September 5.
On offense, the Gladiators completed the map, and on defense, they held the Spark from reaching the second checkpoint, resulting in a 4–3 match victory.
[32] Advancing to the first round of the upper bracket, Los Angeles took on the Vancouver Titans on September 8.
From then on, the Gladiators put on a much better showing, showcasing great ultimate combinations between Chang-hoon "rOar" Gye on Orisa and Gui-un "Decay" Jang on Doomfist.
[34] While they were able to keep the battle competitive, the Shock proved to be too much to handle, as Los Angeles fell on King's Row and Horizon Lunar Colony.
On their attack, the Gladiators completed the map, largely due to a stellar performance by João Pedro "Hydration" Goes Telles on Pharah.