In 2016, he broke contracts by moving the St. Louis Rams to Los Angeles, incurring legal costs for the entire league.

[8] At Cole Camp (Missouri) High School, he played baseball, basketball and ran track.

He founded the Kroenke Group in 1983, a real estate development firm that has built shopping centers and apartment buildings.

In 2016, THF's portfolio was valued at more than $2 billion, including more than 100 projects totaling 20 million square feet, primarily in retail shopping centers.

[10] In 2006, Kroenke, in partnership with the money manager Charles Banks, acquired Screaming Eagle, a winery in Napa Valley.

[14] In August 2017, he came under fire for launching a British outdoor sports television channel that will show regular hunting programmes that includes killing elephants, lions, and other vulnerable African species.

On April 13, 1995, Stan Kroenke helped Georgia Frontiere move the National Football League's Los Angeles Rams from Anaheim to St. Louis by purchasing a 30% share of the team.

[16] In 2010, Kroenke exercised his right of first refusal to purchase the remaining interest in the Rams from the Frontiere estate.

To gain approval from NFL owners, Kroenke agreed to turn over control of the Denver Nuggets and Colorado Avalanche to his son, Josh, by the end of 2010, and he had to give up his majority stake in both teams in December 2014.

[18] On October 7, 2015, the NFL approved transfer of his ownership stake of the Avalanche and Nuggets to his wife, Ann Walton Kroenke.

[21] In 2015, Kroenke said that he was willing to work with Missouri officials and to give them a "complete understanding" of the stadium situation.

To persuade Kroenke to keep the Rams in St. Louis, the city offered to build an open-air stadium dubbed National Car Rental Field in the north riverfront area of downtown.

[31] On January 12, 2016, the NFL approved the Rams' application to move from St. Louis back to Los Angeles with a 30–2 vote; other owners praised Kroenke.

On April 12, 2017, it was reported that the City of St. Louis, St. Louis County, and the Regional Convention and Sports Complex Authority filed a 52-page lawsuit against the NFL and all 32 NFL clubs as defendants (including Stan Kroenke) and seeks damages and restitution of profits.

[35] On November 24, 2021, after four years of litigation, it was announced that the NFL, Kroenke, and the various St. Louis parties had agreed to a $790 million settlement to end the lawsuit.

After the aborted attempt to end the European soccer system, Arsenal fans protested and called for the Kroenke family to sell the club.

[52] In late 2017, Kroenke Sports and Entertainment developed a new esports team franchise named the Los Angeles Gladiators in the newly founded Overwatch League; their inaugural season began on December 6.

They, along with the Los Angeles Gladiators of the Overwatch League, are based out of Hollywood Park next door to where Kroenke's Rams play.

[61][62] In 2023, Kroenke's Denver Nuggets won the NBA Championship, giving him four different sports titles in a 16-month span.