2019 Southern Illinois Salukis football team

Led by fourth-year head coach Nick Hill, the Salukis compiled an overall record of 7–5 with a mark of 5–3 in conference play, placing in a three-way tie for third in the MVFC.

In the MVFC preseason poll released on July 29, 2019, the Salukis were predicted to finish in ninth place.

[1] The Salukis had four players selected to the preseason all-MVFC team.

Davis – RB Defense Anthony Knighton – DL Jeremy Chinn – DB Je'Quan Burton – RS

[3][4] The following Saluki was drafted into the National Football League following the season.