The 2019 Southeast Missouri State Redhawks football team represented Southeast Missouri State University as a member of the Ohio Valley Conference (OVC) during the 2019 NCAA Division I FCS football season.

Led by sixth-year head coach Tom Matukewicz, the Redhawks compiled an overall record of 9–4 with a mark of 7–1 in conference play, sharing the OVC title with Austin Peay.

The team played home games at Houck Stadium in Cape Girardeau, Missouri.

[2] Offense Daniel Santacaterina – QB Kristian Wilkerson – WR

[3][4] The Redhawks received an at-large bid to the NCAA Division I Football Championship playoffs, with a first-round pairing against Illinois State.