It was the sixth event of the 2019 UCI Women's World Tour.

The race started and finished in Oudenaarde, in the province of East Flanders.

Compared to the 2017 and 2018 event, the route is extended four kilometers, totalling 157.4 km, making it the longest women's race in the history of the Tour of Flanders.

[3] It starts in the centre of Oudenaarde, before heading east towards Zottegem where two flat cobbled sectors are addressed, and returning to Oudenaarde, after which a larger loop towards Geraardsbergen begins, which features 10 hills in the Flemish Ardennes.

The top of the Paterberg, the last climb of the day, comes at 13.3 km from the finish, ensued by a flat run-in towards Oudenaarde.