The fifth edition of the Madrid Challenge by La Vuelta, a women's cycling race held in Spain, took place on 14 and 15 September 2019.

[1] The event was organised by ASO, which also organises the Vuelta a España.

It was the 22nd race of the 2019 UCI Women's World Tour.

It was won by Lisa Brennauer of WNT-Rotor Pro Cycling.

The race starts with and 9.3 km individual time trial in Boadilla del Monte, followed by a 98.6 km crit race in Madrid.