The 2019 U.S. Men's Clay Court Championships (also known as the Fayez Sarofim & Co. U.S. Men's Clay Court Championships for sponsorship purposes) was a men's tennis tournament played on outdoor clay courts.

It was the 51st edition of the U.S. Men's Clay Court Championships, and an ATP Tour 250 event on the 2019 ATP Tour.

It took place at River Oaks Country Club in Houston, Texas, United States, from April 8 through April 14, 2019.

The following players received wildcards into the main draw: The following players received entry via the qualifying draw: The following pairs received wildcards into the doubles main draw: