The season did not have a Primera Division tournament; instead, the 2020 Copa de la Liga Profesional was played from October 2020 to January 2021, a cup that was conceived as a contingency competition after the schedule for a regular league season had been repeatedly delayed because of the COVID-19 pandemic.

The second competition was another national cup, the 2021 Copa de la Liga Profesional, from February to May 2021.

Agustín Rossi, Nahuel Molina, Julián Chicco, Franco Cristaldo, Sebastián Pérez, Gonzalo Maroni, Walter Bou, Mateo Retegui and Nazareno Solís returned from their respective loans.

On August 21, Boca confirms that Edwin Cardona is loaned from Tijuana; also, the club announces that has reached an agreement for the transfer of Emanuel Reynoso to Minnesota United FC.

[6] On October 22 Boca beat Caracas 3-0 and ended the group stage of Copa Libertadores in first place.

[7] On October 31 Boca defeated Lanús 2–1 in the first match of 2020 Copa de la Liga Profesional.

Guillermo Fernández was on loan from Cruz Azul, although the club had agreed with the Mexican team a purchase option that expires on December 31, the player communicated that he did not want to continue in Boca.

On December 9, Boca lost 1–0 against Internacional but won 5–4 on penalties, in the quarterfinals the club will play against Racing.

On December 23, Boca defeated Racing 2-0 and advanced to the semifinals of Copa Libertadores, facing Santos of Brazil.

On January 9, Boca drew 2–2 against Argentinos Juniors and advanced to the final of 2020 Copa de la Liga Profesional.

On January 17, Boca won the 2020 Copa de la Liga Profesional after beating Banfield on penalties.

[12] On February 14 Boca drew 2–2 against Gimnasia y Esgrima (LP) in the first match of 2021 Copa de la Liga Profesional.

On March 24 Boca defeated Defensores de Belgrano 3-0 and advanced to the Round of 16 of Copa Argentina.

On May 2 Boca defeated Lanús 1-0 and qualified to the final stages of 2021 Copa de la Liga Profesional.

On May 26 Boca defeated 3–0 against Bolivian The Strongest and qualified to the final stages of 2021 Copa Libertadores.

On May 31 Boca was defeated 4–2 on penalties after a 1–1 draw against Racing, ending the participation in 2021 Copa de la Liga Profesional.