On 19 June Boca announced that Alexis Mac Allister is the first signing of the season, being loaned from Brighton & Hove Albion.

[5] Nicolás Colazo, Franco Cristaldo, Marcelo Torres and Nazareno Solís returned from their loans.

On 12 July, Boca and Gimnasia y Esgrima (LP) reached an agreement for the transfer of forward Jan Carlos Hurtado.

Italian midfielder Daniele de Rossi is new player of the club, after arriving as a free agent.

In the second leg of the Round of 16 of Copa Libertadores, Boca beat Athletico Paranaense 2-0 and advanced to the Quarterfinals, facing Ecuadorian team LDU Quito.

On 5 August, Boca and Marseille reached an agreement for the transfer of forward Darío Benedetto, "Pipa" leaves the club after three years, in which he scored 45 goals in 76 matches.

In the second leg of the Quarterfinals of Copa Libertadores, Boca draw LDU Quito 0-0 and advanced to the Semifinals, facing River Plate, in another edition of Superclásico.

Boca won 1–0 against River the second leg of the Libertadores semifinals Superclásico but lost 2–1 in the aggregate and is eliminated.

Miguel Ángel Russo is the new head coach of the club, after Gustavo Alfaro ended his contract.

Brighton & Hove Albion recalls Alexis Mac Allister, interrupting his loan spell with Boca.

[17] On 31 January, Boca and Dynamo Kyiv reached an agreement for the transfer of defender Carlos Zambrano.

On 10 March, in the second game of Copa Libertadores group stage Boca won 3-0 Independiente Medellín.

[19] On 28 April 2020 AFA announced the abandonment of the Copa de la Superliga and the culmination of the 2019–20 season in all of its competitions due to the COVID-19 pandemic.