[1] As coach Diego Vásquez renewed his contract, he led the team for his 14th consecutive tournament.

Olimpia and Nicaraguan side Real Estelí FC at the 2020 CONCACAF League, F.C.

Motagua was unable to qualify to their second straight CONCACAF Champions League.

[4] The 2020–21 home and away kits were published on 25 September, one day before their debut in the Apertura tournament.

This is a list of players that were playing for Motagua during the 2020–21 season and were called to represent Honduras at different international competitions.