[1] Due to the COVID-19 pandemic, CONCACAF announced on 23 June 2020 that the start of the tournament, which was scheduled to begin on 28 July 2020 and end in November, had been postponed.

[2] On 7 August 2020, they announced the tournament would begin on 20 October and end on 28 January 2021.

The one berth for the North American Zone (NAFU) was allocated to the Canadian Soccer Association through the previous year's Canadian Premier League, where the champions, decided by the Canadian Premier League Finals, contested between the Spring and Fall season champions, qualified.

All of the leagues of Central America employed a split season with two tournaments in one season, so the following teams qualified for the CONCACAF League: If teams from any Central American associations were excluded, they were to be replaced by teams from other Central American associations, with the associations chosen based on results from previous CONCACAF League and CONCACAF Champions League tournaments.

[26][27] Due to CONCACAF's COVID-19 testing protocol, one match was rescheduled to 24 November.

[32] In the quarter-finals, the matchups were determined as follows: The higher-seeded team based on the CONCACAF Club Ranking hosted the single-leg match.

[32] In the play-in, the matchups were determined as follows: The higher-seeded team based on the CONCACAF Club Ranking hosted the single-leg match.

[4] The winners of the play-in round qualified for the 2021 CONCACAF Champions League.

[36] In the semi-finals, the matchups were determined as follows: The higher-seeded team based on the CONCACAF Club Ranking hosted the single-leg match.

Winner SF2), the higher-seeded team based on the CONCACAF Club Ranking hosted the single-leg match.

[37] The top six teams qualified for the 2021 CONCACAF Champions League, i.e., champions, runners-up, both losing semi-finalists, and the two winners of the play-in round contested by the four losing quarter-finalists.