The 2020–21 Grasshopper Club Zurich season is the club's second consecutive season in the Swiss Challenge League, having been relegated from the 2018–19 Swiss Super League one year earlier, after playing in the top tier for 67 years.

[2] The new owners began to reform the club and renew the squad during the summer break, including the signing of several players from Wolverhampton Wanderers.

[3] The first game of the season was played in late September 2020, a delay caused by the COVID-19 pandemic in Switzerland.

[4] Thanks to a 2–1 win against Kriens on the last day of the season, Grasshopper Club Zurich was promoted to the Super League.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.