The 2020–21 season was the 34th season in the history of the Misr Lel Makkasa SC, and the club's 11th consecutive season in the Egyptian Premier League.
In addition to the domestic league, the team participated in the Egypt Cup.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.
Players may hold more than one non-FIFA nationality.
Source: Competitions Source: [citation needed] The match schedule was released on 23 November 2020.