won the MTN 8 cup and finished 3rd in the 2020–21 DStv Premiership and Qualified for the 2021-22 CAF Confederation Cup following Kaizer Chiefs loss to Egyptian Club Al Ahly SC in the 2020-21 CAF Champions League final.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Orlando Pirates player Thabang Monare received an injury and was replaced by Thembinkosi lorch.

Orlando Pirates was drawn with National First Division (NFD) club Uthongathi F.C.

Third round Quarter-finals Orlando Pirates journey came to an end as they were eliminated by Mamelodi Sundowns.

Orlando Pirates won on walkover after Sagrada Esperança withdrew from the second leg in South Africa citing health concerns caused due to the new COVID-19 variant.

CAF Confederation Cup run came to an end after being eliminated by Moroccan Club Raja Casablanca.