The 2020–21 season is Mamelodi Sundowns's 50th season in existence and 25th consecutive season in the South African Premier Division, the top tier of South African soccer.

They will also participate in the Nedbank Cup, the MTN 8 and the CAF Champions League.

Mamelodi Sundowns entired the competition in the Round of 32 Mamelodi Sundowns entered the competition in the first round The draw for the First Round was on 9 November 2020.

The draw for the group stage was held on 8 January 2021

Players with no appearances not included in the list.