The season featured 14 teams from the 2019–20 Persian Gulf Pro League and two new teams promoted from the 2019–20 Azadegan League: Mes Rafsanjan and Aluminium Arak.

[1][2] The 2020–21 season started on 6 November 2020 and was ended on 30 July 2021.

[3] Persepolis won their record-extending 5th consecutive title and 14th title overall (7th in the Pro League era) Note: Flags indicate national team as has been defined under FIFA eligibility rules.

The number of foreign players is restricted to four per Persian Gulf Pro League team, including a slot for a player from AFC countries.

In bold: Players that have been capped for their national team.