The Rays would go on to defeat the Astros in the ALCS, then lose the 2020 World Series to the National League champion Los Angeles Dodgers.

[10] DJ LeMahieu began the game with a single off Rays starter Blake Snell, and came around to score following a wild pitch, a groundout, and a sacrifice fly.

In the bottom of the first, Randy Arozarena tied the game with a solo home run off Yankees starter Gerrit Cole.

The Yankees regained the lead with solo home runs by Kyle Higashioka and Aaron Judge in the top of the fifth, which proved to be Snell's last inning.

Ryan Thompson and Oliver Drake pitched scoreless sixth, seventh, and eighth innings, as did Cole, Chad Green, and Zack Britton.

John Curtiss struggled in the ninth inning for the Rays, giving up an RBI single to Hicks before loading the bases for Giancarlo Stanton, who hit a grand slam to extend the Yankees' lead to 9–3.

A. Happ replaced García after the first inning; in the bottom of the second, Joey Wendle singled and Mike Zunino homered to give the Rays a 3–1 lead.

Glasnow began the fourth by allowing a single to Aaron Hicks and walking Luke Voit, which was followed by another Stanton home run, cutting the score to 5–4.

Pete Fairbanks entered to finish the game for the Rays in the ninth, and ran into trouble after issuing walks to Urshela and Gleyber Torres.

[12] Giancarlo Stanton joined Lou Gehrig and Reggie Jackson as the only Yankees with home runs in four straight postseason games.

The Rays started Charlie Morton, who pitched two 1-2-3 innings to begin the game, but, in the third, Brett Gardner singled, Kyle Higashioka reached on a Willy Adames error, and DJ LeMahieu walked to load the bases.

Aaron Judge scored Gardner on a sacrifice fly, but Morton got Luke Voit to ground out to end the inning.

Luis Cessa replaced Green after the home run, and walked Arozarena, who scored on a Ji-man Choi double, giving the Rays an 8–2 lead.

Giancarlo Stanton hit a two-run home run off Shane McClanahan in the eighth after Voit reached on an error, but Diego Castillo pitched a scoreless ninth to end the game at 8–4 for Tampa Bay.

In the second, Thompson gave up a leadoff home run to Luke Voit and promptly loaded the bases with three straight walks to Brett Gardner, Gleyber Torres and Gio Urshela.

Thompson was able to strike out Kyle Higashioka, but Aaron Judge delivered a sacrifice fly to give the Yankees a 2–0 lead.

Chad Green, Zack Britton, and Aroldis Chapman all pitched scoreless innings in relief of Montgomery to force a Game 5.

2020 ALDS (3–2): Tampa Bay Rays beat New York Yankees This is the first postseason match-up between the Athletics and Astros.

On Yusmeiro Petit's first pitch as reliever, George Springer hit a deep shot to left field to make it 5–2.

The bottom half of the frame saw three pitchers for the Athletics, as a home run from Aledmys Diaz after a lead-off walk tied the game, while Michael Brantley and Alex Bregman each scored in a run on base hits off Yusmeiro Petit before Jake Diekman finished the inning with allowing an RBI single and the final out of a now 7–4 game.

Liam Hendriks closed out the last three innings for the Athletics by allowing just one hit and no runs as they would force a Game 4 in the series.

Jose Altuve led off the inning with a walk, and Michael Brantley responded with a home run to narrow the game to 3–2.

[21][22] This would prove to be the Athletics' final postseason game while the team was based in Oakland, as they will temporarily move to Sacramento in 2025 while a new ballpark in Las Vegas is constructed with the expectation it will open in time for the 2028 season.