Columbus were also set to compete in the U.S. Open Cup, before its cancelation due to the COVID-19 pandemic.

Columbus defeated Seattle Sounders FC, 3–0 in the championship match.

Source: MLS standings Pld = Matches played; Pts = Points; W = Matches won; T = Matches tied; L = Matches lost; GF = Goals for; GA = Goals against; GD = Goal difference On December 5, 2019, the league announced the home openers for every club, with Columbus playing New York City FC at Mapfre Stadium.

[4] Due to the COVID-19 pandemic, the original schedule had to be shortened and was released in installments.

[5] The 2020 edition of the U.S. Open Cup was canceled on August 17 due to concerns about the COVID-19 pandemic.