Shortly before the season began, Offensive Line Assistant Coach D. J. Looney, 31, died of a heart attack while at practice on August 1, 2020.

[1] He was honored at the Week 9 matchup against UAB in his hometown of Birmingham, Alabama, where players all wore Looney's name on their jerseys.

[5] During Week 14, the Cajuns defeated Appalachian State for the first time in school history, bringing their all-time record against the Mountaineers to 1–8.

References':[18] Roster Last update: July 4, 2020 The 2020 schedule consists of 6 home and 6 away games in the regular season.

The Cajuns will play host to Sun Belt foes Georgia Southern, Coastal Carolina, Arkansas State, and South Alabama.

On August 17, McNeese pulled out of the agreement to play Louisiana in the Herbert Heymann Classic on September 5.

[22] On August 20, the Cajuns reached agreements with UAB and Central Arkansas to play them away on October 23 and home on November 21, respectively.