The Golden Eagles played their home games at the M. M. Roberts Stadium in Hattiesburg, Mississippi, and competed in the West Division of Conference USA (CUSA).

Walden himself resigned after four games to become the head coach at Austin Peay and was replaced by Tim Billings.

Listed in the order that they were released The CUSA Media Days will be held virtually for the first time in conference history.

To be released Southern Miss announced its 2020 football schedule on January 8, 2020.

The Golden Eagles had games scheduled against Auburn, Jackson State, Tennessee Tech and UTEP that were canceled due to the COVID-19 pandemic.