The Roadrunners played their home games at the Alamodome in San Antonio, Texas, and competed in the West Division of Conference USA (CUSA).

Listed in the order that they were released The CUSA Media Days were held virtually for the first time in conference history.

[2] The 2020 schedule consisted of 6 home and 6 away games in the regular season.

The Roadrunners had games scheduled against Grambling State, LSU, Old Dominion, and Rice that were canceled due to the COVID-19 pandemic.

[3][4][5] On December 13, the Roadrunners accepted a bid to the Frisco Bowl, to face the SMU Mustangs.