[1] Missouri voters chose electors to represent them in the Electoral College via a popular vote, pitting the Republican Party's nominee, incumbent President Donald Trump of Florida, and running mate Vice President Mike Pence of Indiana against Democratic Party nominee, former Vice President Joe Biden of Delaware, and his running mate Senator Kamala Harris of California.

[47] A bellwether state for the bulk of the 20th century, Missouri has since come to vote reliably Republican in presidential elections.

This has been attributed to a shift in Republican policy towards right-wing populism and social conservatism; the platform has found fertile ground in the state, which lies in the Bible Belt, with Trump carrying 86% of White, born-again/Evangelical Christians.

In addition, the 61% of the vote that Biden won in St. Louis County was the best performance for a Democrat since Lyndon B. Johnson's 1964 landslide.

[48] In other elections, incumbent Republican Mike Parson easily defeated State Auditor Nicole Galloway by 16 points—outperforming Trump—in the governor's race, further testifying to the state's trend towards the GOP, and becoming the best performance for a Republican on the gubernatorial level since John Ashcroft's 1988 victory.