Bernie Sanders, Elizabeth Warren, and former Vice President Joe Biden were the major declared Democratic candidates.

[15] The unaffiliated candidates for president will be listed in this order: Jade Simmons, Kanye West, Brock Pierce.

Ronda Vuillemont-Smith, Lonnie Lu Anderson, Chris Martin, Steve Fair, Linda Huggard, A. J. Ferate, Carolyn McLarty[44] Erin Adams, Danny Chabino, Drew Cook, Kevin Hobbie, Rex Lawhorn, Jay Norton, Victoria Whitfield[45] Judy Eason McIntyre, Eric Proctor, Jeff Berrong, Christine Byrd, Demetrios Bereolos, Pamela Iron, Shevonda Steward[46] Shanda Carter, Terrence Stephens, Hope Stephens, Elizabeth Stephens, Dakota Hooks, Phalanda Boyd, Quincy Boyd[12] April Anderson, Craig Alan Weygandt, Will Flanagan, Tom Krup, Megan Krup, Gretchen Schrupp, David Schrupp[14] Robert Murphy, Susan Darlene Murphy, Richard Prawdzienski, Jessy Artman, David Selinger, Shane Wayne Howell, Angela McCaslin[13] Oklahoma, a majority-White, mainly-rural state sandwiched between the South and the Midwest, has long been a Republican stronghold at the presidential level, although Democrats did well in state-level elections until the 2000s.

Trump also exhibited considerable strength in the historically Democratic region known as "Little Dixie," carrying Oklahoma's 2nd congressional district by 54%.

The counties encompassed by the Cherokee, Choctaw, Chickasaw, Muscogee, Seminole, Osage, and Pawnee reservations were all captured by Trump by large margins.

Oklahoma, often termed the "Buckle of the Bible Belt", is a very religious state, with Trump capturing the Protestant vote by 78%.