In addition to the domestic league, Roma participated in this season's editions of the Coppa Italia and the inaugural edition of the UEFA Europa Conference League, winning the latter tournament for the club's first major trophy since the 2007–08 Coppa Italia.

[2] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Win Draw Loss Fixtures Source: Soccerway Source: Serie A The league fixtures were announced on 14 July 2021.

[31] The draw for the play-off round was held on 2 August.