The 2021–22 season was Frosinone Calcio's third consecutive season in second division of the Italian football league, the Serie B, and the 116th as a football club.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.
Source: Serie B The league fixtures were announced on 24 July 2021.