2021–22 ACF Fiorentina season

In addition to the domestic league, Fiorentina participated in this season's edition of the Coppa Italia.

Gennaro Gattuso was initially hired to be the team's manager in the early summer, but parted ways 23 days after his appointment following disagreements on transfer policy and agent's influence.

Vincenzo Italiano was hired from Spezia as the team's next manager.

[1] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.