It marked Milan's return to Europe's premier knockout competition for the first time since the 2013–14 season.

[1] Milan secured their 19th Italian league title on the last match day of the season, with a club-record tally of 86 points.

Deals officialised beforehand were effective starting from 1 January 2022.

Win Draw Loss Fixtures Source: Soccerway Source: Serie A The league fixtures were announced on 14 July 2021.

[55] The draw for the group stage was held on 26 August 2021.