The 2021–22 American Eagles women's basketball team represented the American University Eagles during the 2021–22 NCAA Division I women's basketball season.

The Eagles were led by ninth-year head coach Megan Gebbia and played their home games at Bender Arena as members of the Patriot League.

As the second seed in the Patriot League tournament they earned a bye into the quarterfinals where they defeated Lafayette, Boston University and Bucknell to win the title.

They received an automatic bid to the NCAA tournament, where they were the fourteenth seed in the Wichita Region.

They earned a bye in to the quarterfinals of the Patriot League tournament where they defeated Army, before losing to Boston University in the semifinals.