Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Win Draw Loss Fixtures Source: Soccerway Source: Serie A The league fixtures were announced on 14 July 2021.

[31] This is the first season with an asymmetrical calendar, i.e., the order of fixtures in the second half of the season (ritorno) is different from the that of the first half (andata).

[32] The draw for the group stage was held on 26 August 2021.

The knockout round play-offs draw was held on 13 December 2021.