In addition to the domestic league, Cagliari participated in this season's edition of the Coppa Italia.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Win Draw Loss Source: Soccerway Source: Serie A The league fixtures were announced on 14 July 2021.