The 2021–22 Coupe de France preliminary rounds, Pays de la Loire was the qualifying competition to decide which teams from the leagues of the Pays de la Loire region of France took part in the main competition from the seventh round.
A total of eleven teams qualified from the Pays de la Loire preliminary rounds.
[1] In 2020–21, Voltigeurs de Châteaubriant and Olympique Saumur FC progressed furthest in the main competition, reaching the round of 16 before losing to Montpellier and Toulouse respectively.
[4] On 21 July 2021, the league published the first round draw along with further details of the structure of the competition.
22 clubs from Régional 1 and 12 from Championnat National 3 entered at the third round stage, along with the qualifier from Saint Pierre and Miguelon.