The 2021–22 season was the 114th season in the existence of Inter Milan and the club's 106th consecutive season in the top division of Italian football.

In addition to the domestic league, Inter participated in this season's editions of the Coppa Italia, the Supercoppa Italiana and the UEFA Champions League, winning the former two tournaments.

Supplier: Nike / Sponsors: Socios.com (front) / Lenovo (back) / DigitalBits (sleeve) Goalkeeper kits Win Draw Loss Fixtures Source: Soccerway Source: Serie A The league fixtures were announced on 14 July 2021.

[86] The draw for the group stage was held on 26 August 2021.

The draw for the round of 16 was held on 13 December 2021.