The 2021–22 Gardner–Webb Runnin' Bulldogs men's basketball team represented Gardner–Webb University in the 2021–22 NCAA Division I men's basketball season.

The Runnin' Bulldogs, led by ninth-year head coach Tim Craft, played their home games at Paul Porter Arena in Boiling Springs, North Carolina as members of the Big South Conference.

3 seed in the Big South tournament, they defeated Campbell in the quarterfinals before losing to Winthrop in the semifinals.

In a season limited due to the ongoing COVID-19 pandemic, the Runnin' Bulldogs finished the 2020–21 season 11–15, 10–10 in Big South play to finish in a three-way tie for fifth place.

They were defeated by Campbell in the quarterfinals of the Big South tournament.