[5] On 24 July, Juventus played a friendly match against Serie C side Cesena, winning 3–1, through goals scored by Koni De Winter, Weston McKennie, and Matías Soulé.

[8] On 8 August, Juventus played the Joan Gamper Trophy against Spanish La Liga side Barcelona at Johan Cruyff Stadium, losing 3–0.

[9] On 14 August, Juventus played a friendly match against Serie A side Atalanta, winning 3–1, thanks to goals scored by Paulo Dybala, Federico Bernardeschi, and Álvaro Morata.

[10] On 17 August, Juventus announced that Kaio Jorge's purchase had been officialised from Brazilian Série A side Santos.

[14] In the 51st minute, the referee awarded a penalty kick after Juventus' goalkeeper Wojciech Szczęsny fouled Tolgay Arslan; Roberto Pereyra scored from the spot reducing the disadvantage.

[17] On 14 September, Juventus made their debut in UEFA Champions League against Swedish side Malmö FF, winning 0–3.

[21] On 2 November, Juventus qualified to the knockout phase of the UEFA Champions League thanks to the 4–2 win against Russian side Zenit Saint Petersburg.

Home win 1–0 against Malmö FF with the only goal scored by Moise Kean in the 18th minute and 3–3 between Zenit Saint Petersburg and Chelsea meant Juventus was seeded in the knockout phase round of 16 draw.

In the second period, Henrikh Mkhitaryan put Roma in front, with Lorenzo Pellegrini scoring the third goal for the home team.

In less than eights minutes, Juventus scored three times: Manuel Locatelli, Dejan Kulusevski and Mattia De Sciglio completed the comeback.

Juan Cuadrado, Daniele Rugani, Paulo Dybala and Álvaro Morata, on penalty, scored for the home team, while the only goal for Sampdoria was provided by Andrea Conti.

[27] On 28 January, Juventus announced that Serbian forward Dušan Vlahović had been bought from Serie A side Fiorentina.

[35] On 22 February, Juventus restarted their campaign in the Champions League, going against Spanish La Liga side Villarreal in the Round of 16 first leg.

The final score was 1–1: Dušan Vlahović put Juventus in front in the first minute, while in the second half Dani Parejo equalised the result.

[37] On 16 March, Juventus faced Spanish La Liga side Villarreal in the Champions League Round of 16 second leg, losing 3–0.

Juventus concluded the Serie A in the fourth place which meant they qualified for the 2022–23 UEFA Champions League, starting from the group stage phase.