The 2021–22 NIFL Premier Intermediate League (known as the Lough 41 Premier Intermediate League for sponsorship reasons) was the fifth season of the NIFL Premier Intermediate League, the third tier of the Northern Ireland Football League - the national football league in Northern Ireland.
The Premier Intermediate League returned after a one-year hiatus, following the cancellation of the 2020–21 season due to the COVID-19 pandemic in Northern Ireland.
Annagh United were the reigning champions from the 2019–20 season, and were promoted to the NIFL Championship.
The season began on 17 August 2021 and concluded on 7 May 2022.
During matches 1–20 each team played every other team twice (home and away).