The Championship returned after a one-year hiatus, following the cancellation of the 2020–21 season due to the COVID-19 pandemic in Northern Ireland.
Newry City were confirmed as champions on the final day of the 2021–22 season.
Runners-up Ballinamallard United missed out on promotion, as the NIFL Premiership play-off was cancelled as a result of the COVID-19 pandemic in Northern Ireland.
The bottom Championship team from the previous season, PSNI, were relegated to the third-tier NIFL Premier Intermediate League.
They were replaced by Annagh United, winners of the Premier Intermediate League.