The 2021–22 Norfolk State Spartans men's basketball team represented Norfolk State University in the 2021–22 NCAA Division I men's basketball season.

The Spartans, led by ninth-year head coach Robert Jones, played their home games at the Joseph G. Echols Memorial Hall in Norfolk, Virginia as members of the Mid-Eastern Athletic Conference.

As a result, they received the conference’s automatic bid to the NCAA tournament as the No.

They defeated North Carolina Central in the quarterfinals of the MEAC tournament,[1] advancing directly to the championship game after their semifinal opponent, North Carolina A&T, had to withdraw due to COVID-19 protocols.

16 seed in the West Region where they defeated Appalachian State in the First Four[4] before losing to overall No.