The 2022 NCAA Division I men's basketball tournament involved 68 teams playing in a single-elimination tournament that determined the National Collegiate Athletic Association (NCAA) Division I men's college basketball national champion for the 2021–22 season.

The 83rd annual edition of the tournament began on March 15, 2022, and concluded with the championship game on April 4 at the Caesars Superdome in New Orleans, Louisiana, with the Kansas Jayhawks defeating the North Carolina Tar Heels, 72–69, overcoming a 16-point first-half deficit (the largest deficit overcome in championship game history), to claim the school's fourth national title.

The defending champions Baylor were defeated by North Carolina in the second round, ensuring the defending champion and at least one top seed was eliminated before the regional semifinals for the fifth consecutive tournament, and at least one double-digit seed (this year, four: 15-seed Saint Peter's, 11-seeds Michigan and Iowa State, and 10-seed Miami) made the Sweet 16 for the 14th straight tournament.

Per the NCAA, "Upsets are defined as when the winner of the game was seeded five or more places lower than the team it defeated."

[12][13] As part of a cycle that began in 2016, TBS televised the 2022 Final Four and the national championship game.

[14][15] The 2022 Tournament was Mark Emmert final season as the NCAA President with Charlie Baker succeeding him starting in 2023.