2021–22 Palermo FC season

Match legend: Sources: Palermo F.C., Soccerway Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

[5][6][7] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

[39] One week before the first official match, Palermo's players composed two teams, Rosa (Pink) and Nero (Black), which faced each other at Stadio Renzo Barbera.

[40] On January Palermo played a friendly against the sicilian Eccellenza club Oratorio S. Ciro e Giorgio from Marineo, profiting by the long Christmas break due to the postponement of matchdays 21 and 22.

This match replaces the canceled Serie C game against Catania due to the exclusion of the other sicilian club from league.