The 2021–22 Premier 15s is the 5th season of the Premier 15s (23rd including editions of the previous Women's Premiership), of the top flight of English domestic women's rugby union competition and the second to be sponsored by Allianz.

Saracens Women, who finished top of the league table during the regular season, won their third Premiers 15s title on 3 June 2022, after defeating Exeter Chiefs Women by 43–21 in the play-off final.

The team was selected by a panel of five media experts–Jessica Hayden, Nick Heath, Kat Merchant, Sara Orchard and Fiona Thomas.

The Allianz Cup saw the Premier 15s clubs ranked by their previous finishing position and drawn in two pools of five, with clubs playing each other once in two home games, two away games, one bye week over five rounds.

The Allianz Cup final will be played at the home venue of the winning semi-finalist club with the highest points’ difference.